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Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS‐induced expression of IL‐12 and IL‐23 in human dendritic cells
Author(s) -
Wei WenChi,
Liu ChihPin,
Yang WenChin,
Shyur LieFen,
Sheu JyhHorng,
Chen SweyShen,
Yang NingSun
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a0414-206rr
Subject(s) - biology , mtorc2 , microbiology and biotechnology , mtorc1 , pi3k/akt/mtor pathway , cancer research , signal transduction
Blockage of mTORC2 activity inhibits LPS‐induced expression of IL‐12 and IL‐23 in human DCs, resulting in the regulation of Th1 and Th17 cell responses.
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