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WASp‐dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts
Author(s) -
Malinova Dessislava,
Fritzsche Marco,
Nowosad Carla R.,
Armer Hannah,
Munro Peter M. G.,
Blundell Michael P.,
Charras Guillaume,
Tolar Pavel,
Bouma Gerben,
Thrasher Adrian J.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a0215-050rr
Subject(s) - immunological synapse , microbiology and biotechnology , biology , synapse , cytoskeleton , actin cytoskeleton , wiskott–aldrich syndrome protein , t cell , dendritic spine , podosome , actin remodeling of neurons , cell , immune system , immunology , neuroscience , t cell receptor , genetics , hippocampal formation
Novel DC podosomes surround the central MHCII cluster to stabilize the IS; a driver role for the DC actin cytoskeleton.