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Ikaros 6 protects acute lymphoblastic leukemia cells against daunorubicin‐induced apoptosis by activating the Akt‐FoxO1 pathway
Author(s) -
Han Juan,
Jin Runming,
Zhang Meiling,
Guo Qing,
Zhou Fen
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a0116-040rr
Subject(s) - daunorubicin , apoptosis , lymphoblastic leukemia , biology , protein kinase b , cancer research , leukemia , foxo1 , immunology , genetics
Ik6, an upstream regulator of Akt‐FoxO1 pathway, can protect ALL cells against daunorubicin‐induced apoptosis; a possible therapeutic target in ALL.