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Parkinson disease–associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response
Author(s) -
Park Jeongho,
Lee JangWon,
Cooper Scott C.,
Broxmeyer Hal E.,
Can Jason R.,
Kim Chang H.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1a0417-147rr
Subject(s) - myelopoiesis , biology , myeloid , lrrk2 , bone marrow , progenitor cell , immune system , immunology , haematopoiesis , cancer research , stem cell , microbiology and biotechnology , gene , mutation , genetics
The PD‐associated LRRK2 G2019S gene abnormally alters marrow myelopoiesis and peripheral myeloid cell differentiation, leading to decreased Th17 cell activity.