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Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long‐lived maternal T cells
Author(s) -
Barton Brendan M.,
Xu Rong,
Wherry E. John,
Porrett Paige M.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1a0316-135r
Subject(s) - biology , immunology , cd8 , antigen , pregnancy , fetus , cytotoxic t cell , context (archaeology) , t cell , effector , immune system , transplantation , medicine , in vitro , genetics , paleontology
Dysfunctional memory CD8 + T cells differentiate in the maternal repertoire which promotes pregnancy success, but can threaten subsequent tissue grafts.