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Putting the brakes on leukocyte chemotaxis: an interview with Dr. Ramesh K. Ganju
Author(s) -
Rosenberg Helene F.
Publication year - 2007
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1306678
Subject(s) - biology , chemotaxis , microbiology and biotechnology , genetics , receptor
The manuscript, “Slit-2/Robo-1 Modulates the CXCL12/ CXCR4-induced Chemotaxis of T cells” was selected as a Pivotal Advance because it is the first to propose a molecular mechanism via which a Slit /Robo (Roundabout receptor) complex inhibits leukocyte chemotaxis. Specifically, in this manuscript, Dr. Ganju and colleagues demonstrate that the Slit/Robo complex inhibits Akt phosphorylation and Rac activation that result from the interaction of the chemokine SDF-1 (CXCL12) with its seven-transmembrane receptor, CXCR4. The Slit ligands and Robo receptors, originally identified as modulators of neuronal migration, have more recently been characterized as inhibitors of specific chemokine-mediated inflammatory responses [1].