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CTLA4, T cell function, and long term immunity: an interview with Dr. Mark K. Slifka
Author(s) -
Rosenberg Helene F.
Publication year - 2007
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1306535
Subject(s) - library science , biology , immunity , immunology , gerontology , medicine , immune system , computer science
Cytotoxic T lymphocyte antigen-4 (CTLA-4/CD152) is a member of the CD28 family of T cell effector antigens. Current belief, based primarily on results from gene-deleted mice, is that CTLA-4 promotes suppression of T cell proliferation. In this manuscript, Mark Slifka and colleagues compare antiviral responses of unmanipulated virus-specific CTLA-4 and CTLA-4 T cells. The results of this work suggest that the CTLA-4 antigen has no specific role in suppressing T cell proliferation in response to viral stimulation.