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Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE 2
Author(s) -
Bourdonnay Emilie,
Serezani Carlos H.,
Aronoff David M.,
PetersGolden Marc
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1211590
Subject(s) - microbiology and biotechnology , kinase , biology , akt1 , protein kinase a , nadph oxidase , protein kinase b , signal transduction , reactive oxygen species
In lung macrophages, inhibition of p40phox by PGE 2 represents a brake on bacterial killing, and likely contributes to impaired lung innate immunity.