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Caspase‐8 and caspase‐9 mediate thymocyte apoptosis in Trypanosoma cruzi acutely infected mice
Author(s) -
FariasdeOliveira Désio Aurélio,
VillaVerde Déa Maria Serra,
Nunes Panzenhagen Pedro Henrique,
Silva dos Santos Danielle,
Berbert Luiz Ricardo,
Savino Wilson,
Meis Juliana
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1211589
Subject(s) - biology , thymocyte , apoptosis , glucocorticoid , trypanosoma cruzi , caspase 8 , caspase , cd8 , caspase 3 , programmed cell death , immunology , t cell , caspase 9 , immune system , parasite hosting , biochemistry , world wide web , computer science
Thymus atrophy and thymocyte apoptosis during T. cruzi infection is mediated by both the extrinsic and intrinsic death pathway, and involves caspase activation.