Premium
Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM‐1
Author(s) -
Feng Chiguang,
Zhang Lei,
Almulki Lama,
Faez Sepideh,
Whitford Melissa,
HafeziMoghadam Ali,
Cross Alan S.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210708
Subject(s) - sialidase , cd18 , biology , integrin alpha m , neuraminidase , epitope , integrin , microbiology and biotechnology , icam 1 , lymphocyte function associated antigen 1 , intercellular adhesion molecule 1 , biochemistry , cell adhesion molecule , flow cytometry , receptor , enzyme , immunology , antibody
Removal of sialyl residues on β2 integrin and ICAM‐1 by sialidase activity, mobilized during PMN activation, is an important regulator of leukocyte recruitment.