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The dectin‐1/inflammasome pathway is responsible for the induction of protective T‐helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
Author(s) -
Cheng ShihChin,
Veerdonk Frank L.,
Lenardon Megan,
Stoffels Monique,
Plantinga Theo,
Smeekens Sanne,
Rizzetto Lisa,
Mukaremera Liliane,
Preechasuth Kanya,
Cavalieri Duccio,
Kanneganti Thirumala Devi,
Meer Jos W. M.,
Kullberg Bart Jan,
Joosten Leo A. B.,
Gow Neil A. R.,
Netea Mihai G.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210702
Subject(s) - candida albicans , inflammasome , biology , hypha , microbiology and biotechnology , immune system , corpus albicans , inflammation , immunology
Invading C. albicans hyphae are recognized by macrophages, activate the caspase‐1/IL‐1β pathway, and lead to the activation of IL‐17 pathway to control the C. albicans infection.