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Molecular analysis of the membrane insertion domain of proteinase 3, the Wegenerˈs autoantigen, in RBL cells: implication for its pathogenic activity
Author(s) -
Kantari Chahrazade,
Millet Arnaud,
Gabillet Julie,
Hajjar Eric,
Broemstrup Torben,
Pluta Paula,
Reuter Nathalie,
WitkoSarsat Véronique
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210695
Subject(s) - proteinase 3 , proinflammatory cytokine , biology , microbiology and biotechnology , inflammation , immunology , myeloperoxidase
Expressed in RBL cells, proteinase 3 membrane anchorage via its unique hydrophobic patch is pivotal for its pro‐inflammatory and proliferative functions.