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Human PD‐L1‐overexpressing porcine vascular endothelial cells induce functionally suppressive human CD4 + CD25 hi Foxp3 + Treg cells
Author(s) -
Ding Qing,
Lu Liming,
Zhou Xiaorong,
Zhou Yun,
Chou KuangYen
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210691
Subject(s) - biology , foxp3 , xenotransplantation , immunology , microbiology and biotechnology , transfection , transgene , transplantation , immune system , cell culture , medicine , gene , biochemistry , genetics
Human PD‐L1‐overexpressing porcine vascular endothelial cells induced human CD4 + CD25 hi Foxp3 + Treg cells have higher suppressive potency and mediate their suppressive function partially through IL‐10 and CD73.