Premium
Toll‐like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia‐inducible factor 1α (HIF1A) and result in differential HIF1A‐dependent gene expression
Author(s) -
Jantsch Jonathan,
Wiese Melanie,
Schödel Johannes,
Castiglione Kirstin,
Gläsner Joachim,
Kolbe Sophie,
Mole David,
Schleicher Ulrike,
Eckardt KaiUwe,
Hensel Michael,
Lang Roland,
Bogdan Christian,
Schnare Markus,
Willam Carsten
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210683
Subject(s) - hif1a , biology , hypoxia (environmental) , signal transduction , microbiology and biotechnology , transcription factor , cancer research , angiogenesis , gene , chemistry , genetics , oxygen , organic chemistry
In contrast to hypoxia, TLR‐Iigands stabilize HIFlA in a predominantly MYD88‐dependent manner and result in activation of a different set of HIFlA target genes.