Toll‐like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia‐inducible factor 1α (HIF1A) and result in differential HIF1A‐dependent gene expression | Zendy

Jantsch Jonathan | Zendy; Wiese Melanie | Zendy; Schödel Johannes | Zendy; Castiglione Kirstin | Zendy; Gläsner Joachim | Zendy; Kolbe Sophie | Zendy; Mole David | Zendy; Schleicher Ulrike | Zendy; Eckardt KaiUwe | Zendy; Hensel Michael | Zendy; Lang Roland | Zendy; Bogdan Christian | Zendy; Schnare Markus | Zendy; Willam Carsten | Zendy

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Toll‐like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia‐inducible factor 1α (HIF1A) and result in differential HIF1A‐dependent gene expression

Author(s) -

Jantsch Jonathan,

Wiese Melanie,

Schödel Johannes,

Castiglione Kirstin,

Gläsner Joachim,

Kolbe Sophie,

Mole David,

Schleicher Ulrike,

Eckardt KaiUwe,

Hensel Michael,

Lang Roland,

Bogdan Christian,

Schnare Markus,

Willam Carsten

Publication year - 2011

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.1210683

Subject(s) - hif1a , biology , hypoxia (environmental) , signal transduction , microbiology and biotechnology , transcription factor , cancer research , angiogenesis , gene , chemistry , genetics , oxygen , organic chemistry

In contrast to hypoxia, TLR‐Iigands stabilize HIFlA in a predominantly MYD88‐dependent manner and result in activation of a different set of HIFlA target genes.

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