Premium
Interleukin‐12 treatment down‐regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells
Author(s) -
Huang Yong,
Lei YingFeng,
Zhang Hai,
Zhang Mingjie,
Dayton Andrew
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210674
Subject(s) - stat4 , biology , microbiology and biotechnology , interleukin 12 , apoptosis , cytolysis , interleukin 21 , stimulation , signal transduction , immunology , t cell , immune system , cytotoxic t cell , in vitro , stat , biochemistry , stat3 , endocrinology
Negative feedback mechanisms preventing NK cells from mounting an uncontrolled immune reaction after prolonged IL‐12 stimulation include apostosis and down‐regulation of STAT4.