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Interleukin‐27 and interleukin‐23 modulate human plasmacell functions
Author(s) -
Cocco Claudia,
Morandi Fabio,
Airoldi Irma
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210660
Subject(s) - biology , interleukin , interleukin 2 , interleukin 4 , immunology , cytokine
Human plasmablasts/plasmacells express complete IL‐27 and IL‐23 receptors; and IL‐27 but not IL‐23 exerts chemotactic properties on these cells and modulates different chemokines/chemokine receptors, yet both cytokines induce secretion of immunoglobulin (Ig)M and IgG.