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Technical Advance: Soluble OX40 molecule mimics regulatory T cell modulatory activity on FcɛRI‐dependent mast cell degranulation
Author(s) -
Sibilano Riccardo,
Gri Giorgia,
Frossi Barbara,
Tripodo Claudio,
Suzuki Ryo,
Rivera Juan,
MacDonald Andrew S.,
Pucillo Carlo E.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1210651
Subject(s) - degranulation , effector , biology , microbiology and biotechnology , in vivo , mast cell , signal transduction , cell , cell signaling , immunology , receptor , biochemistry
New method to study inhibition of mast cell degranulation by showing that soluble OX40 mimics activity of Treg interaction by binding and inhibiting MC degranulation.