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SHIP negatively regulates Flt3L‐derived dendritic cell generation and positively regulates MyD88‐independent TLR‐induced maturation
Author(s) -
Antignano Frann,
Ibaraki Mariko,
Ruschmann Jens,
Jagdeo Julienne,
Krystal Gerald
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1209825
Subject(s) - biology , microbiology and biotechnology , cd86 , cd11c , dendritic cell , pi3k/akt/mtor pathway , signal transduction , phenotype , t cell , immunology , immune system , gene , genetics
SHIP plays an important role in the maturation and DC‐induced Ag‐specific T cell proliferation downstream of MyD88‐independent signaling pathways in Flt3L‐DCs.
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