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Myelin ingestion alters macrophage antigen‐presenting function in vitro and in vivo
Author(s) -
Zwam Marloes,
Samsom Janneke N.,
Nieuwenhuis Edward E.,
Melief MarieJosé,
WierengaWolf Annet F.,
Dijke I. Esmé,
Talens Simone,
Meurs Marjan,
Voerman Jane S.,
Boven Leonie A.,
Laman Jon D.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1209813
Subject(s) - myelin , biology , macrophage , antigen presentation , antigen , antigen presenting cell , microbiology and biotechnology , immunology , myelin basic protein , inflammation , t cell , population , in vitro , immune system , central nervous system , medicine , neuroscience , biochemistry , environmental health
Macrophage myelin ingestion results in a population of macrophages that induces T‐cell proliferation, restricts detrimental Th1 differentiation, and suppresses EAE.