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The involvement of β‐actin in the signaling of transmembrane TNF‐α‐mediated cytotoxicity
Author(s) -
Chen Hui,
Xiao Li,
Zhang Hailong,
Liu Na,
Liu Tao,
Liu Lili,
Hu Xin,
Yan Dan,
Yang Kun,
Yin Bingjiao,
Wang Jing,
Li Qingfen,
Li Zhuoya
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1209812
Subject(s) - microbiology and biotechnology , biology , traf2 , actin , cytotoxicity , gene knockdown , signal transduction , cytoskeleton , actin cytoskeleton , apoptosis , cell , biochemistry , in vitro , tumor necrosis factor receptor
B‐actin functions in tmTNF‐α‐mediated apoptotic signaling through dissociation of TRAF2 and cFLIP from and recruitment of RIP1 to TNFR2, inhibiting NF‐κB activation and activating caspase‐8.