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LPS‐induced cytokine production in human dendritic cells is regulated by sialidase activity
Author(s) -
Stamatos Nicholas M.,
Carubelli Ivan,
Vlekkert Diantha,
Bonten Erik J.,
Papini Nadia,
Feng Chiguang,
Venerando Bruno,
dˈAzzo Alessandra,
Cross Alan S.,
Wang LaiXi,
Gomatos Peter J.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1209776
Subject(s) - sialidase , cytokine , sialic acid , biology , monocyte , glycoconjugate , microbiology and biotechnology , immunology , biochemistry , neuraminidase , virus
Neu1 and Neu3 are up‐regulated as monocytes differentiate into DCs; and desialylation of cell surface glycoconjugates by one or both sialidase promotes cytokine production.