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Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL‐4 and STAT6
Author(s) -
Chapoval Svetlana,
Dasgupta Preeta,
Dorsey Nicolas J.,
Keegan Achsah D.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1209772
Subject(s) - foxp3 , gata3 , biology , effector , immunology , microbiology and biotechnology , transcription factor , stat6 , il 2 receptor , immune system , cellular differentiation , treg cell , t helper cell , stat4 , interleukin 4 , t cell , signal transduction , genetics , gene , stat , stat3
Review discusses the regulation of Th2 cells by Tregs and vice versa and focuses on the interplay between the IL‐4‐activated STAT6/GATA3 pathway and Foxp3.