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Pancreatic lipase‐related protein 2 (PLRP2) induction by IL‐4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity
Author(s) -
Alves Bryce N.,
Leong Jeff,
Tamang David L.,
Elliott Viki,
Edelnant Jillian,
Redelman Doug,
Singer Cherie A.,
Kuhn Andrew R.,
Miller Rita,
Lowe Mark E.,
Hudig Dorothy
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1208766
Subject(s) - biology , cytotoxic t cell , cytotoxicity , lipase , gene , immune system , immunology , microbiology and biotechnology , cancer research , biochemistry , enzyme , in vitro
Ablation of the gene for the lipase PLRP2 reduces perforin‐dependent CTL cytotoxicity, even under conditions when PLRP2 is unexpressed, raising serious doubts about PLRP2s function in cytotoxicity.