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The inflammasome in pathogen recognition and inflammation
Author(s) -
Sutterwala Fayyaz S.,
Ogura Yasunori,
Flavell Richard A.
Publication year - 2007
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1206755
Subject(s) - inflammasome , biology , innate immune system , proinflammatory cytokine , microbiology and biotechnology , caspase , inflammation , aim2 , pyrin domain , pattern recognition receptor , caspase 1 , receptor , immunology , immune system , programmed cell death , apoptosis , genetics
The nucleotide‐binding oligomerization domain‐like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Some NLR family members promote the activation of proinflammatory caspases within multiprotein complexes, called inflammasomes. Recent studies analyzing mice deficient in various components of the inflammasome have provided insight into the role of these molecules in host defense against pathogens and in autoinflammatory disorders. Here, we review these studies and propose that membrane disruption leads to activation of the inflammasome.