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The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis
Author(s) -
Belkina Anna C.,
Blanton Wanda P.,
Nikolajczyk Barbara S.,
Denis Gerald V.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1112588
Subject(s) - bromodomain , biology , microbiology and biotechnology , haematopoiesis , epigenetics , chromatin , stem cell , cancer research , genetics , gene
Brd2 lentivirus transduction of hematopoietic stem cells and immune reconstitution of mice shows that the Brd2 pathway affects both hematopoiesis and mitogenic proliferation of mature B cells.