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MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis
Author(s) -
Gharib Sina A.,
Johnston Laura K.,
Huizar Isham,
Birkland Timothy P.,
Hanson Josiah,
Wang Ying,
Parks William C.,
Manicone Anne M.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1112587
Subject(s) - macrophage polarization , bleomycin , pulmonary fibrosis , biology , macrophage , m2 macrophage , fibrosis , proinflammatory cytokine , alveolar macrophage , immunology , lung , microbiology and biotechnology , in vivo , inflammation , cancer research , pathology , in vitro , medicine , biochemistry , genetics , chemotherapy
MMP28 promotes alternatively activated (M2) macrophage function, and regulates the fibrotic response in the lung.