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Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages
Author(s) -
Movita Dowty,
Kreefft Kim,
Biesta Paula,
Oudenaren Adri,
Leenen Pieter J. M.,
Janssen Harry L. A.,
Boonstra Andre
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1111566
Subject(s) - biology , kupffer cell , tlr9 , macrophage , microbiology and biotechnology , mononuclear phagocyte system , tlr4 , mannose receptor , population , tumor necrosis factor alpha , cd40 , inflammation , immunology , in vitro , gene expression , medicine , gene , biochemistry , cytotoxic t cell , dna methylation , environmental health
Kupffer cells are endocytic, yet weak producers of proinflammatory cytokines, as compared against splenic and peritoneal macrophages.