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Mechanisms of triglyceride accumulation in activated macrophages
Author(s) -
Feingold Kenneth R.,
Shigenaga Judy K.,
Kazemi Mahmood R.,
McDonald Carol M.,
Patzek Sophie M.,
Cross Andrew S.,
Moser Arthur,
Grunfeld Carl
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1111537
Subject(s) - cd36 , macrophage , glut1 , tlr4 , biology , medicine , endocrinology , lipolysis , zymosan , adipose triglyceride lipase , glucose uptake , microbiology and biotechnology , biochemistry , signal transduction , adipose tissue , gene , in vitro , insulin
TLR activation by multiple pathways leads to triglyceride accumulation in macrophages that could contribute to the accelerated atherosclerosis seen in chronic infections and inflammatory diseases.