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Cathepsin X cleavage of the β 2 integrin regulates talin‐binding and LFA‐1 affinity in T cells
Author(s) -
Jevnikar Zala,
Obermajer Nataša,
Doljak Bojan,
Turk Samo,
Gobec Stanislav,
Švajger Urban,
Hailfinger Stephan,
Thome Margot,
Kos Janko
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1110622
Subject(s) - biology , integrin , cleavage (geology) , microbiology and biotechnology , cathepsin l , cathepsin d , cathepsin , biochemistry , enzyme , receptor , paleontology , fracture (geology)
Cathepsin X finely tunes the affinity of LFA‐1 by cleaving the β2 integrin cytoplasmic tail, thus influencing LFA‐1‐mediated T cell functions.