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Glucocorticoids inhibit dendritic cell maturation induced by Toll‐like receptor 7 and Toll‐like receptor 8
Author(s) -
Larangé Alexandre,
Antonios Diane,
Pallardy Marc,
KerdineRömer Saadia
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1110615
Subject(s) - tlr7 , biology , agonist , cd86 , dendritic cell , toll like receptor , microbiology and biotechnology , stimulation , receptor , gene silencing , cd40 , c c chemokine receptor type 7 , immunology , inflammation , immune system , t cell , innate immune system , endocrinology , chemokine , gene , in vitro , biochemistry , cytotoxic t cell , chemokine receptor
Glucocorticoids alter dendritic cells maturation in response to TLR7 or TLR8 agonists through a mechanism requiring glucocorticoid receptor activity but not MKP‐1.