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Crucial involvement of the CX3CR1‐CX3CL1 axis in dextran sulfate sodium‐mediated acute colitis in mice
Author(s) -
Kostadinova Feodora I.,
Baba Tomohisa,
Ishida Yuko,
Kondo Toshikazu,
Popivanova Boryana K.,
Mukaida Naofumi
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1109768
Subject(s) - cx3cr1 , colitis , cx3cl1 , bone marrow , chemokine , biology , inflammation , nitrotyrosine , immunology , endocrinology , pharmacology , nitric oxide synthase , chemokine receptor , nitric oxide
Dextran sulfate sodium ingestion causes CX3CR1‐expressing macrophages to accumulate in intestinal submucosal areas and to express inducible NO synthetase, thereby causing acute colitis.