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Exocytosis of azurophil and arginase 1‐containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation
Author(s) -
Rotondo Rita,
Bertolotto Maria,
Barisione Gaia,
Astigiano Simonetta,
Mandruzzato Susanna,
Ottonello Luciano,
Dallegri Franco,
Bronte Vincenzo,
Ferrini Silvano,
Barbieri Ottavia
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1109737
Subject(s) - azurophilic granule , ionomycin , biology , exocytosis , microbiology and biotechnology , phagocyte , extracellular , arginase , gelatinase , biochemistry , phagocytosis , secretion , immunology , inflammation , arginine , enzyme , myeloperoxidase , intracellular , amino acid
Arginase‐dependent inhibition of T cell proliferation results from regulated exocytosis of gelatinase and azurophil granules released by activated polymorphonuclear cells.