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A proinsulin 74‐90 ‐derived protease‐resistant, altered peptide ligand increases TGF‐β1 secretion in PBMC from patients with type 1 diabetes mellitus
Author(s) -
Aalst Denise,
Kalbacher Hubert,
Palesch David,
Zou Fang,
Spyrantis Andreas,
Rosinger Silke,
Boehm Bernhard O.,
Burster Timo
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1109713
Subject(s) - proinsulin , protease , biology , cytokine , immune system , secretion , peripheral blood mononuclear cell , immunology , endocrinology , medicine , biochemistry , diabetes mellitus , enzyme , in vitro
Proinsulin‐based protease‐resistant altered peptide ligands modulate proinsulin‐reactive T cells to secret the anti‐inflammatory cytokine TGF‐β1.