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Low‐dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality
Author(s) -
Pan Pinhua,
Cardinal Jon,
Dhupar Rajeev,
Rosengart Matthew R.,
Lotze Michael T.,
Geller David A.,
Billiar Timothy R.,
Tsung Allan
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1108713
Subject(s) - hmgb1 , sepsis , systemic administration , pharmacology , biology , lethality , inflammation , cytokine , immunology , in vitro , systemic inflammation , medicine , in vivo , toxicology , biochemistry , microbiology and biotechnology
Platinating agents in general, and cisplatin specifically, may be a novel candidate approach to the treatment of sepsis.