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Clostridium difficile toxin B differentially affects GPCR‐stimulated Ca 2+ responses in macrophages: independent roles for Rho and PLA 2
Author(s) -
Rebres Robert A.,
Moon Christina,
DeCamp Dianne,
Lin KengMean,
Fraser Iain D.,
Milne Stephen B.,
Roach Tamara I. A.,
Brown H. Alex,
Seaman William E.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1108708
Subject(s) - biology , g protein coupled receptor , microbiology and biotechnology , signal transduction , receptor , clostridium difficile toxin a , biochemistry , clostridium difficile , antibiotics
Distinct activities of toxin B up‐regulate PLCβ3 or down‐regulate PLCβ4‐dependent IP3‐Ca 2+ coupling.