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Altered eosinophil profile in mice with ST6Gal‐1 deficiency: an additional role for ST6Gal‐1 generated by the P1 promoter in regulating allergic inflammation
Author(s) -
Nasirikenari Mehrab,
Chandrasekaran E. V.,
Matta Khushi L.,
Segal Brahm H.,
Bogner Paul N.,
Lugade Amit A.,
Thanavala Yasmin,
Lee James J.,
Lau Joseph T. Y.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1108704
Subject(s) - eosinophil , inflammation , biology , eosinophilia , immunology , s100a9 , eotaxin , allergic inflammation , eosinophilic , asthma , genetics
ST6Gal‐1 is a participant in regulating not only Th1 but also Th2 responses; ST6Gal‐1 deficiency can lead to the development of more severe allergic inflammation with excessive eosinophil production.