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Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors
Author(s) -
Wright Adam K. A.,
Rao Satish,
Range Simon,
Eder Christiane,
Hofer Thomas P. J.,
Frankenberger Marion,
Kobzik Lester,
Brightling Chris,
Grigg Jonathan,
Ziegler–Heitbrock Loems
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1108699
Subject(s) - mannose receptor , scavenger receptor , phagocytosis , cd14 , biology , receptor , inflammation , immunology , sputum , macrophage , immune system , receptor expression , flow cytometry , cd64 , microbiology and biotechnology , in vitro , pathology , medicine , endocrinology , tuberculosis , biochemistry , lipoprotein , cholesterol
In the airways of classical CF cases there is a high number of newly immigrated small macrophages, which are disabled with respect to scavenger receptor–mediated phagocytosis.