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Contribution of viral and cellular cytokines to Kaposi's sarcoma‐associated herpesvirus pathogenesis
Author(s) -
Gasperini Paola,
Sakakibara Shuhei,
Tosato Giovanna
Publication year - 2008
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1107777
Subject(s) - biology , pathogenesis , virology , immunology , viral pathogenesis , sarcoma , gammaherpesvirinae , human herpesvirus , herpesviridae , virus , viral replication , viral disease , pathology , medicine
Kaposi's sarcoma (KS)‐associated herpesvirus is associated with the proliferative/malignant disorders KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD) in patients with AIDS. In spite of recent advances in the treatment of KS, PEL and MCD represent therapeutic challenges. Recent advances in dissecting the pathogenesis of these diseases have indicated that the viral cytokine IL‐6 and the cellular cytokines/growth factors IL‐10, IL‐6, stromal cell‐derived factor 1, and vascular endothelial growth factor are important contributors to the growth, survival, and spread of PEL and MCD and are therefore potential targets for drug development.