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BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice
Author(s) -
Truong Wayne,
Hancock Wayne W.,
Plester Jennifer C.,
Merani Shaheed,
Rayner David C.,
Thangavelu Govindarajan,
Murphy Kenneth M.,
Anderson Colin C.,
Shapiro A. M. James
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1107753
Subject(s) - btla , biology , phenotype , immunology , function (biology) , disease , lymphocyte , t lymphocyte , immune system , medicine , microbiology and biotechnology , genetics , gene
Targeting coinhibitory T cell receptors using monoclonal antibodies attenuates autoimmune diabetes by altering lymphocyte number and function.