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The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement
Author(s) -
Weinberg Andrew D.,
Evans Dean E.,
Thalhofer Colin,
Shi Tom,
Prell Rodney A.
Publication year - 2004
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1103586
Subject(s) - biology , microbiology and biotechnology , t cell , proinflammatory cytokine , cd28 , tumor necrosis factor alpha , cytokine , effector , il 2 receptor , inflammation , zap70 , immunology , immune system
OX40 (CD134), a membrane‐bound member of the tumor necrosis factor‐receptor superfamily, is expressed primarily on activated CD4 + T cells. Following engagement on the cell surface, OX40 delivers a costimulatory signal that leads to potent, proinflammatory effects. Engagement of OX40 during antigen (Ag)‐specific stimulation of T cells leads to increased production of memory T cells, increased migration of Ag‐specific T cells, enhanced cytokine production by effector T cells, and the ability to break peripheral T cell tolerance in vivo. Therefore, OX40 engagement in vivo could have important ramifications for the enhancement of vaccine strategies and inhibition of unwanted inflammation. This review summarizes the molecular and cellular events that occur following OX40 engagement during Ag‐specific T cell activation.