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DLX genes as targets of ALL ‐1: DLX 2,3,4 down‐regulation in t(4;11) acute lymphoblastic leukemias
Author(s) -
Ferrari Nicoletta,
Palmisano Giulio L.,
Paleari Laura,
Basso Giuseppe,
Mangioni Manuela,
Fidanza Vincenzo,
Albini Adriana,
Croce Carlo M.,
Levi Giovanni,
Brigati Claudio
Publication year - 2003
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1102581
Subject(s) - biology , gene , lymphoblastic leukemia , genetics , computational biology , leukemia
Dlx genes constitute a gene family thought to be essential in morphogenesis and development. We show here that in vertebrate cells, Dlx genes appear to be part of a regulatory cascade initiated by acute lymphoblastic leukemia (ALL)‐1, a master regulator gene whose disruption is implicated in several human acute leukemias. The expression of Dlx2 , Dlx3 , Dlx5 , Dlx6 , and Dlx7 was absent in All‐1 −/− mouse embryonic stem cells and reduced in All‐1 +/− cells. In leukemic patients affected by the t(4;11)(q21;q23) chromosomal abnormality, the expression of DLX 2, DLX 3, and DLX 4 was virtually abrogated. Our data indicate that Dlx genes are downstream targets of ALL‐1 and could be considered as important tools for the study of the early leukemic cell phenotype.