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Involvement of P2Y receptors in the differentiation of haematopoietic cells
Author(s) -
Sak Katrin,
Boeynaems JeanMarie,
Everaus Hele
Publication year - 2003
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1102561
Subject(s) - biology , receptor , p2y receptor , microbiology and biotechnology , haematopoiesis , metabotropic receptor , ionotropic effect , cellular differentiation , signal transduction , stem cell , purinergic receptor , biochemistry , glutamate receptor , gene
The effects of extracellular nucleotides are mediated by multiple P2X ionotropic receptors and G protein‐coupled P2Y receptors. These receptors are ubiquitous, but few physiological roles have been firmly identified. In this review article, we present a survey of the functional expression of P2Y receptors in the different haematopoietic lineages by analyzing the selectivity of these cells for the various adenine and uracil nucleotides as well as the second messenger signaling pathways involved. The pharmacological profiles of metabotropic nucleotide receptors are different among myeloid, megakaryoid, erythroid, and lymphoid cells and change during differentiation. A role of P2Y receptors in the differentiation and maturation of blood cells has been proposed: In particular the P2Y 11 receptor seems to be involved in the granulocytic differentiation of promyelocytes and in the maturation of monocyte‐derived dendritic cells. It is suggested that the role of P2Y receptors in the maturation of blood cells may be more important than believed so far.