Premium
Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma
Author(s) -
Abad Catalina,
Nobuta Hiroko,
Li Jiaxi,
Kasai Atsushi,
Yong William H.,
Waschek James A.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1012531
Subject(s) - myeloid derived suppressor cell , biology , myeloid , immune system , cancer research , stat3 , medulloblastoma , cd8 , immunology , myelopoiesis , cancer , haematopoiesis , suppressor , microbiology and biotechnology , signal transduction , stem cell , genetics
Targeted mutation of STAT3 in myeloid cells dramatically altered the relative abundance of specific immune cell types within tumors, with no impact on tumor incidence.