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MGL signaling augments TLR2‐mediated responses for enhanced IL‐10 and TNF‐α secretion
Author(s) -
Vliet Sandra J.,
Bay Sylvie,
Vuist Ilona M.,
Kalay Hakan,
GarcíaVallejo Juan J.,
Leclerc Claude,
Kooyk Yvette
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1012520
Subject(s) - biology , mapk/erk pathway , tlr2 , microbiology and biotechnology , signal transduction , secretion , immune system , phosphorylation , creb , cytokine , tumor necrosis factor alpha , c type lectin , transcription factor , immunology , tlr4 , biochemistry , gene
The C‐type lectin MGL activates the ERK‐p90RSK‐CREB axis, which together with TLR2 signaling leads to enhanced secretion of IL‐10 and TNFα.