z-logo
Premium
MGL signaling augments TLR2‐mediated responses for enhanced IL‐10 and TNF‐α secretion
Author(s) -
Vliet Sandra J.,
Bay Sylvie,
Vuist Ilona M.,
Kalay Hakan,
GarcíaVallejo Juan J.,
Leclerc Claude,
Kooyk Yvette
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1012520
Subject(s) - biology , mapk/erk pathway , tlr2 , microbiology and biotechnology , signal transduction , secretion , immune system , phosphorylation , creb , cytokine , tumor necrosis factor alpha , c type lectin , transcription factor , immunology , tlr4 , biochemistry , gene
The C‐type lectin MGL activates the ERK‐p90RSK‐CREB axis, which together with TLR2 signaling leads to enhanced secretion of IL‐10 and TNFα.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here