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Activation of type I interferon‐dependent genes characterizes the “core response” induced by CpG DNA
Author(s) -
Steinhagen Folkert,
Meyer Corinna,
Tross Debra,
Gursel Mayda,
Maeda Takahiro,
Klaschik Sven,
Klinman Dennis M.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1011522
Subject(s) - biology , tlr9 , gene , cpg site , interferon , innate immune system , secretion , effector , cpg oligodeoxynucleotide , immune system , microbiology and biotechnology , gene expression , immunology , genetics , dna methylation , biochemistry
Structurally diverse CpG oligonucleotides have a shared ability to activate IFN‐dependent ‘core genes’ with antiviral activity while maintaining sequence‐specific effects on human pDC.