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Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2‐A “peptide walking” study
Author(s) -
Dahan Iris,
MolshanskiMor Shahar,
Pick Edgar
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1011507
Subject(s) - nadph oxidase , biochemistry , biology , peptide , oxidase test , enzyme , prenylation , phagocyte , rac gtp binding proteins , rac1 , microbiology and biotechnology , signal transduction , phagocytosis
Synthetic peptides corresponding to specific domains in the Nox2 dehydrogenase region inhibit NADPH oxidase activity in vitro by interfering with FAD‐ and NADPH‐related redox reactions.