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Cell surface localization and release of the candidate tumor suppressor Ecrg4 from polymorphonuclear cells and monocytes activate macrophages
Author(s) -
Baird Andrew,
Coimbra Raul,
Dang Xitong,
Lopez Nicole,
Lee Jisook,
Krzyzaniak Michael,
Winfield Robert,
Potenza Bruce,
Eliceiri Brian P.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1011503
Subject(s) - biology , flow cytometry , cell culture , microbiology and biotechnology , monocyte , cell , tumor suppressor gene , gene , immunology , carcinogenesis , biochemistry , genetics
Ecrg4 is a sentinel peptide tethered on the surface of neutrophils and monocytes that is shed upon cell activation with fMLF or LPS, and activates macrophages.