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A role for STAT3 and cathepsin S in IL‐10 down‐regulation of IFN‐γ‐induced MHC class II molecule on primary human blood macrophages
Author(s) -
Chan Lally L. Y.,
Cheung Benny K. W.,
Li James C. B.,
Lau Allan S. Y.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1009659
Subject(s) - biology , antigen processing , cathepsin s , antigen presentation , mhc class ii , antigen , cd74 , interferon gamma , cathepsin l , cathepsin , cathepsin b , immune system , microbiology and biotechnology , major histocompatibility complex , signal transduction , mhc class i , t cell , immunology , biochemistry , enzyme
IL‐10‐STAT3 down‐regulation of IFN‐γ‐induced MHC‐II antigen presentation is due to inhibition of cathepsin S and independent of JAK/STAT and NF‐κB pathways.
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