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Pivotal Advance: Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution
Author(s) -
Jia Nan,
Semba Umeko,
Nishiura Hiroshi,
Kuniyasu Akihiko,
Nsiama Tienabe K.,
Nishino Norikazu,
Yamamoto Tetsuro
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1009649
Subject(s) - c5a receptor , chemotaxis , secretagogue , biology , receptor , mutant , biochemistry , peptide , microbiology and biotechnology , g protein coupled receptor , complement system , immunology , gene , antibody
The C5a receptor can induce plain chemotaxis or chemotaxis with secretion in neutrophils depending upon a single amino acid residue difference of its ligand.