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Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis
Author(s) -
Davé Shaival H.,
Tilstra Jeremy S.,
Matsuoka Katsuyoshi,
Li Fengling,
DeMarco Richard A.,
BeerStolz Donna,
Sepulveda Antonia R.,
Fink Mitchell P.,
Lotze Michael T.,
Plevy Scott E.
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1008662
Subject(s) - hmgb1 , colitis , biology , cytokine , inflammation , secretion , immunology , microbiology and biotechnology , endocrinology
In two murine models of the human inflammatory bowel diseases, treatment with ethyl pyruvate ameliorated multiple features of active colitis, possibly by inhibiting expression and release of the damage‐associated molecular pattern molecule HMGB1 from inflamed intestinal mucosa.